LIPID-PEROXIDATION AND HOMOCYSTEINE INDUCED TOXICITY

被引：57

作者：

JONES, BG ^{[1
]}

ROSE, FA ^{[1
]}

TUDBALL, N ^{[1
]}

机构：

[1] UNIV WALES COLL CARDIFF,DEPT BIOCHEM,MUSEUM AVE,POB 903,CARDIFF CF1 1ST,WALES

来源：

ATHEROSCLEROSIS | 1994年 / 105卷 / 02期

关键词：

LIPID PEROXIDATION; HOMOCYSTEINE; ENDOTHELIAL CELLS; H2O2; HO-CENTER-DOT;

D O I：

10.1016/0021-9150(94)90046-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Homocysteine induced toxicity has been examined in cultures of human umbilical vein endothelial cells. The toxic effects of the amino acid alone and the amino acid plus Cu2+ could be prevented by catalase and decreased by desferal, when either was present in the culture medium. When desferal was allowed to accumulate intracellularly, no significant protection from homocysteine induced toxicity was observed. Even though lipid peroxidation accompanied the toxicity induced by homocysteine and homocysteine plus Cu2+, inhibition of lipid peroxidation in either case had no effect on cell viability. The significance of these results is discussed.

引用

页码：165 / 170

页数：6

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