SERUM CA-125 CONCENTRATION IN ENDOMETRIOSIS PATIENTS - ROLE OF PELVIC AND PERITONEAL IRRITATION

被引：9

作者：

GARZETTI, GG

CIAVATTINI, A

TRANQUILLI, AL

ARDUINI, D

ROMANINI, C

机构：

[1] Institute of Obstetrics and Gynecology, Ancona University, Rome

[2] Department of Obstetrics and Gynecology, University of 'Tor Vergata', Rome

来源：

GYNECOLOGICAL ENDOCRINOLOGY | 1994年 / 8卷 / 01期

关键词：

ENDOMETRIOSIS; CA-125; PERITONEAL IRRITATION; OVARY;

D O I：

10.3109/09513599409028454

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum CA-125 concentrations were investigated pre-operatively in 91 consecutive women undergoing laparoscopy for infertility, pelvic pain and/or annexial cysts. The presence and extent of endometriosis were carefully assessed, including the American Fertility Society stage of disease, and implant and adhesion scores. Postoperative CA-125 measurements were obtained in 32 of 53 endometriosis patients and evaluated with respect to clinical evolution of the disease. Serum levels of CA-125 were significantly increased in patients with endometriosis (46.5 +/- 39.5 vs. 13.5 +/- 7.3 U/ml in controls, p < 0. 00 1) and correlated with the severity of disease. A positive correlation (r = 0.7, p < 0.001) was observed between adhesion score and CA-125 levels, while the relationship with implant score was not significant (r = 0.3, p = 0.07). CA-125 level was also significantly increased in women with peritoneal endometriosis (70.7 +/- 47.3 vs. 33.5 +/- 25.6 U/ml for those with ovarian endometriosis), and in these patients the post-operative CA-125 level was significantly related to the clinical evolution of the disease, being higher in patients whose disease recurred compared to those with negative follow-up, irrespective of the adhesion score. We conclude that in endometriosis patients, serum CA-125 level is directly related to the adhesion score and peritoneal involvement, suggesting a central role of pelvic and peritoneal irritation in the increased level of this serum marker.

引用

页码：27 / 31

页数：5

共 14 条

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