LIPID-PEROXIDATION INHIBITOR ATTENUATES NOISE-INDUCED TEMPORARY THRESHOLD SHIFTS

被引：70

作者：

QUIRK, WS

SHIVAPUJA, BG

SCHWIMMER, CL

SEIDMAN, MD

机构：

[1] WAYNE STATE UNIV, DEPT OTOLARYNGOL, MICROCIRCULAT LAB, DETROIT, MI 48201 USA

[2] HENRY FORD HOSP, DEPT OTOLARYNGOL HEAD & NECK SURG, DIV NEUROTOL SKULL BASE SURG, OTOL RES LAB, W BLOOMFIELD, MI 48322 USA

来源：

HEARING RESEARCH | 1994年 / 74卷 / 1-2期

关键词：

NOISE INDUCED HEARING LOSS; TEMPORARY THRESHOLD SHIFTS; U74389F; FREE OXYGEN RADICALS; LIPID PEROXIDATION;

D O I：

10.1016/0378-5955(94)90189-9

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The purpose of this study was to investigate the protective effects of U74389F (Upjohn Co. Kalamazoo, MI), a 21-aminosteroid/lipid peroxidation inhibitor, and a member of the lazaroid drug class, on temporary threshold shifts in animals exposed to prolonged noise stimulation. Animals treated with U74389F and exposed to noise showed attenuated cochlear action potential threshold (CAP) shifts and cochlear microphonic (CM) when compared to non-drug treated noise-exposed subjects. These data suggest that inhibition of FOR induced lipid peroxidation is an important mechanism in noise-induced asymptotic temporary threshold shifts.

引用

页码：217 / 220

页数：4

共 29 条

[1] EFFECT OF ALLOPURINOL (ZYLORIC) ON PATIENTS UNDERGOING OPEN-HEART SURGERY [J].