POTASSIUM CHANNEL OPENERS - CLINICAL-APPLICATIONS IN ISCHEMIC-HEART-DISEASE - OVERVIEW OF CLINICAL EFFICACY OF NICORANDIL

被引：25

作者：

KNIGHT, C ^{[1
]}

PURCELL, H ^{[1
]}

FOX, K ^{[1
]}

机构：

[1] ROYAL BROMPTON NATL HEART & LUNG HOSP,LONDON SW3 6NP,ENGLAND

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1995年 / 9卷

关键词：

NICORANDIL; ANGINA; CARDIOPROTECTION;

D O I：

10.1007/BF00878470

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nicorandil is a balanced arterial and venodilator that may also possess cardioprotective properties via its activation of ATP-sensitive potassium channels. It has a number of beneficial hemodynamic effects and has been shown to be effective in treating angina with similar efficacy as the currently available antianginal agents. In addition, it may have useful effects in unstable and variant angina. In this review we examine the hemodynamic effects of nicorandil and discuss the currently available data on its clinical efficacy, both in isolation and in comparison with other agents.

引用

页码：229 / 236

页数：8

共 32 条

[1] EFFECTS OF NICORANDIL ON CORONARY CIRCULATION IN PATIENTS WITH ISCHEMIC HEART-DISEASE - COMPARISON WITH NITROGLYCERIN [J].

AIZAWA, T ;

OGASAWARA, K ;

KATO, K .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1987, 10 :S123-S129

[2]

ARAKI H, 1987, CLIN THER, V9, P174

[3] NICORANDIL ATTENUATES MYOCARDIAL DYSFUNCTION ASSOCIATED WITH TRANSIENT ISCHEMIA BY OPENING ATP-DEPENDENT POTASSIUM CHANNELS [J].

AUCHAMPACH, JA ;

CAVERO, I ;

GROSS, GJ .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1992, 20 (05) :765-771

[4] A CONTROLLED SINGLE-DOSE STUDY OF THE EFFICACY, DOSE-RESPONSE AND DURATION OF ACTION OF NICORANDIL IN ANGINA-PECTORIS [J].

CAMM, AJ ;

MALTZ, MB .

AMERICAN JOURNAL OF CARDIOLOGY, 1989, 63 (21) :J61-J65

[5] ACUTE HEMODYNAMIC-EFFECTS OF SINGLE-DOSE NICORANDIL IN CORONARY-ARTERY DISEASE [J].

COLTART, DJ ;

SIGNY, M .

AMERICAN JOURNAL OF CARDIOLOGY, 1989, 63 (21) :J34-J39

[6] A DOUBLE-BLIND COMPARISON OF NICORANDIL AND METOPROLOL IN STABLE EFFORT ANGINA-PECTORIS [J].

DISOMMA, S ;

LIGUORI, V ;

PETITTO, M ;

CAROTENUTO, A ;

BOKOR, D ;

DEDIVITIIS, O ;

DEDIVITIIS, M .

CARDIOVASCULAR DRUGS AND THERAPY, 1993, 7 (01) :119-123

[7]

DORING G, 1992, J CARDIOVASC PHARM, V20, pS74

[8] USEFULNESS OF NICORANDIL IN CONGESTIVE HEART-FAILURE [J].

GALIE, N ;

VARANI, E ;

MAIELLO, L ;

BORIANI, G ;

BOSCHI, S ;

BINETTI, G ;

MAGNANI, B .

AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (05) :343-348

[9] CARDIOPROTECTIVE EFFECTS OF NICORANDIL [J].

GROSS, GJ ;

AUCHAMPACH, JA ;

MARUYAMA, M ;

WARLTIER, DC ;

PIEPER, GM .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1992, 20 :S22-S28

[10] A DOUBLE-BLIND COMPARISON OF THE LONG-TERM EFFICACY OF A POTASSIUM CHANNEL OPENER AND A CALCIUM-ANTAGONIST IN STABLE ANGINA-PECTORIS [J].

GUERMONPREZ, JL ;

BLIN, P ;

PETERLONGO, F .

EUROPEAN HEART JOURNAL, 1993, 14 :30-34

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