THE CHICKEN GABA(A) RECEPTOR-ALPHA-1 SUBUNIT - CDNA SEQUENCE AND LOCALIZATION OF THE CORRESPONDING MESSENGER-RNA

被引：43

作者：

BATESON, AN ^{[1
]}

HARVEY, RJ ^{[1
]}

WISDEN, W ^{[1
]}

GLENCORSE, TA ^{[1
]}

HICKS, AA ^{[1
]}

HUNT, SP ^{[1
]}

BARNARD, EA ^{[1
]}

DARLISON, MG ^{[1
]}

机构：

[1] MRC,MOLEC NEUROBIOL UNIT,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND

来源：

MOLECULAR BRAIN RESEARCH | 1991年 / 9卷 / 04期

基金：

英国医学研究理事会;

关键词：

BENZODIAZEPINE PHARMACOLOGY; CDNA CLONING; CHICKEN BRAIN; GABA(A) RECEPTOR; INSITU HYBRIDIZATION; RECEPTOR SUBTYPE;

D O I：

10.1016/0169-328X(91)90081-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report the sequence of a complementary DNA (cDNA) that encodes the chicken GABA(A) receptor alpha-1 subunit, which is extremely homologous to mammalian alpha-1 subunits. The distribution of alpha-1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the alpha-1 subunit may not necessarily be restricted to receptors having BZI pharmacology.

引用

页码：333 / 339

页数：7

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