COMPARATIVE PHARMACOKINETICS OF SILIPIDE AND SILYMARIN IN RATS

被引：124

作者：

MORAZZONI, P

MONTALBETTI, A

MALANDRINO, S

PIFFERI, G

机构：

[1] INVERNI BEFFA RES & DEV LABS,I-20141 MILAN,ITALY

[2] UNIV MILAN,IST CHIM FARMACEUT,I-20131 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1993年 / 18卷 / 03期

关键词：

FLAVANOLIGNAN; SILYBIN; SILYMARIN; SILIPIDE; IDB; 1016; PHARMACOKINETICS;

D O I：

10.1007/BF03188811

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The plasma level profile and the biliary excretion of silybin, the main flavanolignan component of silymarin, were evaluated in rats after single equimolar oral doses (200 mg/kg, expressed as silybin equivalents) of the silybin-phosphatidylcholine complex silipide (laboratory code IdB 1016) and of silymarin. Silybin was assayed by using a specific HPLC method which allowed also the determination of other flavanolignans present in the biological fluids after administration of silymarin (i.e. silydianin, silycristin and isosilybin).

引用

页码：289 / 297

页数：9

共 22 条

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