POSSIBLE INVOLVEMENT OF THE TRANSCRIPTION FACTOR ISGF3-GAMMA IN VIRUS-INDUCED EXPRESSION OF THE IFN-BETA GENE

被引：44

作者：

KAWAKAMI, T

MATSUMOTO, M

SATO, M

HARADA, H

TANIGUCHI, T

KITAGAWA, M

机构：

[1] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,SUITA,OSAKA 565,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT IMMUNOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

FEBS LETTERS | 1995年 / 358卷 / 03期

关键词：

INTERFERON BETA; TRANSCRIPTION FACTOR; VIRAL INFECTION; ISGF3; IRF;

D O I：

10.1016/0014-5793(94)01426-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two virus-inducible transcription factors, IRF-1 and IRF-2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF-1 or IRF-2 alleles have revealed the existence of IRF-1-dependent and -independent pathways mediating IFN-beta gene induction. Here we report that the expression of an IRF family member ISGF3 gamma is induced upon viral infection in IRF-1-/-, IRF-2-/- embryonic fibroblasts. Furthermore, ISGF3 gamma can bind to a virus-inducible promoter element in the IFN-beta gene. These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation.

引用

页码：225 / 229

页数：5

共 27 条

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