A DIRECT, HIGHLY SENSITIVE ASSAY FOR CYTOCHROME-P-450 CATALYZED O-DEETHYLATION USING A NOVEL COUMARIN ANALOG

被引:58
作者
DELUCA, JG
DYSART, GR
RASNICK, D
BRADLEY, MO
机构
关键词
D O I
10.1016/0006-2952(88)90436-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1731 / 1739
页数:9
相关论文
共 10 条
[1]  
BURKE MD, 1981, BIOCHEM PHARMACOL, V30, P181, DOI 10.1016/0006-2952(81)90076-9
[2]   ETHOXYPHENOXAZONES, PENTOXYPHENOXAZONES, AND BENZYLOXYPHENOXAZONES AND HOMOLOGS - A SERIES OF SUBSTRATES TO DISTINGUISH BETWEEN DIFFERENT INDUCED CYTOCHROMES-P-450 [J].
BURKE, MD ;
THOMPSON, S ;
ELCOMBE, CR ;
HALPERT, J ;
HAAPARANTA, T ;
MAYER, RT .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (18) :3337-3345
[3]   A NEW HIGHLY SENSITIVE ASSAY FOR ETHOXYCOUMARIN DE-ETHYLASE IN CULTURED-HEPATOCYTES [J].
DEGRAEVE, J ;
KREMERS, P ;
FRANKINET, C ;
GIELEN, J .
ANALYTICAL BIOCHEMISTRY, 1980, 104 (02) :419-424
[4]  
GREENLEE WF, 1978, J PHARMACOL EXP THER, V205, P596
[5]   ENZYMATIC ACTIVATION OF CHEMICALS TO TOXIC METABOLITES [J].
GUENGERICH, FP ;
LIEBLER, DC .
CRC CRITICAL REVIEWS IN TOXICOLOGY, 1985, 14 (03) :259-307
[6]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[7]  
PROUGH BA, 1978, METODS ENZYMOL, V51, P372
[8]   CRITICAL-EVALUATION OF 7-ETHOXYCOUMARIN O-DEETHYLASE ACTIVITY MEASUREMENT IN INTACT ISOLATED RAT HEPATOCYTES [J].
ROGIERS, V ;
ADRIAENSSENS, L ;
VANDENBERGHE, Y ;
GEPTS, E ;
CALLAERTS, A ;
VERCRUYSSE, A .
XENOBIOTICA, 1986, 16 (09) :817-826
[9]  
THOMAS PE, 1976, J BIOL CHEM, V251, P1385
[10]   O-DEALKYLATION OF 7-ETHOXYCOUMARIN BY LIVER-MICROSOMES - DIRECT FLUOROMETRIC TEST [J].
ULLRICH, V ;
WEBER, P .
HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1972, 353 (07) :1171-&