TREATMENT OF EXPERIMENTAL HEMORRHAGE WITH COLLOID-CRYSTALLOID MIXTURES

Thirty-six splenectomized dogs were subjected to acute loss of 30% blood volume and resuscitated with colloid solution alone, crystalloid solution alone, or mixtures of colloid and crystalloid solutions. Certain dose-dependent disadvantageous effects associated with either type fluid alone were avoided by employing mixtures of solutions. Depletion of extravascular fluid, and the bleeding tendency associated with colloid use alone was not seen with appropriate mixtures. Excess water deposition in tissues and cardiovascular instability associated with crystalloid solution alone were absent. While ideal results were not obtained in any case, the optimal mixture in this study consisted of 1 part of 6% dextran solution and 4 parts of Hartmann's (lactate Ringer's) solution administered in a volume equal to three times the blood loss. © 1969.