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REVISED STRUCTURE OF PEPTIDE ANTIBIOTIC ESPERIN ESTABLISHED BY MASS SPECTROMETRY

被引：35
作者：
THOMAS, DW
ITO, T
机构：
[1] Meiji Seika Kaisha, Ltd., Yokohama
来源：
TETRAHEDRON | 1969年 / 25卷 / 09期
关键词：
D O I：
10.1016/S0040-4020(01)82819-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The structures of the antibiotic esperin and of esperinic acid were re-examined using the techniques of N-permethylation and mass spectrometry. The structure of esperinic acid is revised to RCHOHCH2CO.Glu. Leu. Leu. Val. Asp. Leu. Leu(Val). OH, where R is a mixture of C10H21, C11H23, and C12H25, and the C-terminal residue contains a 30% replacement by valine. Esperin (7) contains the same sequence with a lactone formed by the OH group of the fatty acid constituent and the carboxylic acid function of the aspartic acid residue. © 1969.
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页码：1985 / &
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