THE N-TERMINAL REGION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS ENVELOPE GLYCOPROTEIN-GP120 CONTAINS POTENTIAL BINDING-SITES FOR CD4

被引:42
作者
SYU, WJ [1 ]
HUANG, JH [1 ]
ESSEX, M [1 ]
LEE, TH [1 ]
机构
[1] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115
关键词
D O I
10.1073/pnas.87.10.3695
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human immunodeficiency virus (HIV) vaccines targeted at blocking HIV-CD4 interactions are expected to be less affected by the sequence heterogeneity of HIV than those targeted at variable regions of the envelope outercoat glycoprotein, gp120. All potential CD4 binding sites identified thus far in HIV are localized in the C-terminal region of gp120. In this study we demonstrate that the N-terminal region of p120 also contains conserved residues critical for binding to CD4 and that gp120-CD4 interactions can be blocked by an antiserum with binding specificity to an N-terminal region of gp120. These results suggest that not all potential CD4 binding sites are present in the C-terminal region of gp120 and that an alternative HIV vaccine development strategy may have to include the N-terminal gp120 region as a component to raise effective CD4-blocking antibodies.
引用
收藏
页码:3695 / 3699
页数:5
相关论文
共 27 条
[1]   GENETIC-VARIABILITY OF THE AIDS VIRUS - NUCLEOTIDE-SEQUENCE ANALYSIS OF 2 ISOLATES FROM AFRICAN PATIENTS [J].
ALIZON, M ;
WAINHOBSON, S ;
MONTAGNIER, L ;
SONIGO, P .
CELL, 1986, 46 (01) :63-74
[2]   ANTIBODY-RESPONSES IN EARLY HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 INFECTION IN HEMOPHILIACS [J].
CHOU, MJ ;
LEE, TH ;
HATZAKIS, A ;
MANDALAKI, T ;
MCLANE, MF ;
ESSEX, M .
JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (04) :805-811
[3]   EFFECTS OF MUTATIONS IN HYPERCONSERVED REGIONS OF THE EXTRACELLULAR GLYCOPROTEIN OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 ON RECEPTOR-BINDING [J].
CORDONNIER, A ;
RIVIERE, Y ;
MONTAGNIER, L ;
EMERMAN, M .
JOURNAL OF VIROLOGY, 1989, 63 (10) :4464-4468
[4]   SINGLE AMINO-ACID CHANGES IN HIV ENVELOPE AFFECT VIRAL TROPISM AND RECEPTOR-BINDING [J].
CORDONNIER, A ;
MONTAGNIER, L ;
EMERMAN, M .
NATURE, 1989, 340 (6234) :571-574
[5]   THE CD4 (T4) ANTIGEN IS AN ESSENTIAL COMPONENT OF THE RECEPTOR FOR THE AIDS RETROVIRUS [J].
DALGLEISH, AG ;
BEVERLEY, PCL ;
CLAPHAM, PR ;
CRAWFORD, DH ;
GREAVES, MF ;
WEISS, RA .
NATURE, 1984, 312 (5996) :763-767
[6]   EPITOPE MAPPING OF THE HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 GP120 WITH MONOCLONAL-ANTIBODIES [J].
DOWBENKO, D ;
NAKAMURA, G ;
FENNIE, C ;
SHIMASAKI, C ;
RIDDLE, L ;
HARRIS, R ;
GREGORY, T ;
LASKY, L .
JOURNAL OF VIROLOGY, 1988, 62 (12) :4703-4711
[7]   ISOLATION OF RAS GTP-BINDING MUTANTS USING AN INSITU COLONY-BINDING ASSAY [J].
FEIG, LA ;
PAN, BT ;
ROBERTS, TM ;
COOPER, GM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4607-4611
[8]   A MOLECULAR CLONE OF HTLV-III WITH BIOLOGICAL-ACTIVITY [J].
FISHER, AG ;
COLLALTI, E ;
RATNER, L ;
GALLO, RC ;
WONGSTAAL, F .
NATURE, 1985, 316 (6025) :262-265
[9]  
HAMMARSKJOLD ML, 1989, J VIROL, V63, P1959
[10]   LYMPHOCYTE-T T4 MOLECULE BEHAVES AS THE RECEPTOR FOR HUMAN RETROVIRUS LAV [J].
KLATZMANN, D ;
CHAMPAGNE, E ;
CHAMARET, S ;
GRUEST, J ;
GUETARD, D ;
HERCEND, T ;
GLUCKMAN, JC ;
MONTAGNIER, L .
NATURE, 1984, 312 (5996) :767-768