CONTINUOUS GENERATION OF NADH FROM NAD+ AND FORMATE USING A HOMOGENEOUS CATALYST WITH ENHANCED MOLECULAR-WEIGHT IN A MEMBRANE REACTOR

被引：72

作者：

STECKHAN, E ^{[1
]}

HERRMANN, S ^{[1
]}

RUPPERT, R ^{[1
]}

THOMMES, J ^{[1
]}

WANDREY, C ^{[1
]}

机构：

[1] FORSCHUNGSZENTRUM JULICH, INST BIOTECHNOL, W-5170 JULICH 1, GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 1990年 / 29卷 / 04期

关键词：

D O I：

10.1002/anie.199003881

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Bonding the RhIII complex 1 to polyethylene glycol (MW 20 000) leads to a high molecular weight redox catalyst suitable for continuous generation of the cofactors NADH and NADPH. With the aid of a newly designed flow‐through membrane reactor it has proven possible to achieve an NAD⊕ conversion of 40–45% (turnover number 16.9 h−1, space‐time yield 44.3mmol L−1 d−1). Since the reactivity towards polyethylene glycol‐bound NAD⊕ remains constant, this catalyst is also suited to use in a continuously operating enzyme‐membrane reactor. (Formula Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：388 / 390

页数：3

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