An appraisal of the efficacy of the antiviral R 61837 in rhinovirus infections in human volunteers

被引：13

作者：

Barrow, G. I. ^{[1
]}

Higgins, P. G. ^{[1
]}

Tyrrell, D. A. J. ^{[1
]}

Andries, K. ^{[2
]}

机构：

[1] Harvard Hosp, MRC Common Cold Unit, Salisbury SP2 8BW, Wilts, England

[2] Janssen Res Fdn, Beerse, Belgium

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1990年 / 1卷 / 05期

关键词：

D O I：

10.1177/095632029000100501

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The efficacy of the antiviral R 61837 in experimental colds in three previously reported volunteer trials and one new trial is reviewed here. It was dissolved in a new vehicle, hydroXY-beta-cyclodextrin, and used as a nasal spray. A substantial reduction in illness occurred when given prophylactically and during the incubation period but not when used therapeutically.

引用

页码：279 / 283

页数：5

共 11 条

[1] AI- Nakib W., 1986, J ANTIMICROB CHEMOTH, V18, P119
[2] AI-Nakib W., 1987, ARCH VIROL, V92, P255
[3] INTRANASAL CHALCONE, RO 09-0410, AS PROPHYLAXIS AGAINST RHINOVIRUS INFECTION IN HUMAN VOLUNTEERS
ALNAKIB, W
HIGGINS, PG
BARROW, I
TYRRELL, DAJ
LENOXSMITH, I
ISHITSUKA, H
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1987, 20 (06) : 887 - 892
[4] SUPPRESSION OF COLDS IN HUMAN VOLUNTEERS CHALLENGED WITH RHINOVIRUS BY A NEW SYNTHETIC DRUG (R61837)
ALNAKIB, W
HIGGINS, PG
BARROW, GI
TYRRELL, DAJ
ANDRIES, K
VANDENBUSSCHE, G
TAYLOR, N
JANSSEN, PAJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (04) : 522 - 525
[5] A NEW GENERATION OF MORE POTENT SYNTHETIC ANTIRHINOVIRUS COMPOUNDS - COMPARISON OF THEIR MICS AND THEIR SYNERGISTIC INTERACTIONS
ALNAKIB, W
TYRRELL, DAJ
[J]. ANTIVIRAL RESEARCH, 1987, 8 (04) : 179 - 187
[6] INVITRO ACTIVITY OF R-61837, A NEW ANTIRHINOVIRUS COMPOUND
ANDRIES, K
DEWINDT, B
DEBRABANDER, M
STOKBROEKX, R
JANSSEN, PAJ
[J]. ARCHIVES OF VIROLOGY, 1988, 101 (3-4) : 155 - 167
[7] BEARE AS, 1977, CHEMOPROPHYLAXIS VIR, V2, P27
[8] DRUG-RESISTANT RHINOVIRUSES FROM THE NOSE OF EXPERIMENTALLY TREATED VOLUNTEERS
DEARDEN, C
ALNAKIB, W
ANDRIES, K
WOESTENBORGHS, R
TYRRELL, DAJ
[J]. ARCHIVES OF VIROLOGY, 1989, 109 (1-2) : 71 - 81
[9] INTRANASAL INTERFERON-ALPHA-2 TREATMENT OF EXPERIMENTAL RHINOVIRAL COLDS
HAYDEN, FG
GWALTNEY, JM
[J]. JOURNAL OF INFECTIOUS DISEASES, 1984, 150 (02) : 174 - 180
[10] THE SITE OF ATTACHMENT IN HUMAN RHINOVIRUS-14 FOR ANTIVIRAL AGENTS THAT INHIBIT UNCOATING
SMITH, TJ
KREMER, MJ
LUO, M
VRIEND, G
ARNOLD, E
KAMER, G
ROSSMANN, MG
MCKINLAY, MA
DIANA, GD
OTTO, MJ
[J]. SCIENCE, 1986, 233 (4770) : 1286 - 1293

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