An appraisal of the efficacy of the antiviral R 61837 in rhinovirus infections in human volunteers

被引:13
作者
Barrow, G. I. [1 ]
Higgins, P. G. [1 ]
Tyrrell, D. A. J. [1 ]
Andries, K. [2 ]
机构
[1] Harvard Hosp, MRC Common Cold Unit, Salisbury SP2 8BW, Wilts, England
[2] Janssen Res Fdn, Beerse, Belgium
关键词
D O I
10.1177/095632029000100501
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The efficacy of the antiviral R 61837 in experimental colds in three previously reported volunteer trials and one new trial is reviewed here. It was dissolved in a new vehicle, hydroXY-beta-cyclodextrin, and used as a nasal spray. A substantial reduction in illness occurred when given prophylactically and during the incubation period but not when used therapeutically.
引用
收藏
页码:279 / 283
页数:5
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