INCREASE OF CALMODULIN ACTIVATOR IN HYPERTENSION - MODULATION BY DIETARY-SODIUM AND CALCIUM

被引：11

作者：

CHANG, E ^{[1
]}

KUNES, J ^{[1
]}

HAMET, P ^{[1
]}

TREMBLAY, J ^{[1
]}

机构：

[1] CLIN RES INST MONTREAL, MOLEC PATHOPHYSIOL LAB, 110 PINE AVE W, MONTREAL H2W 1R7, QUEBEC, CANADA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 08期

基金：

英国医学研究理事会;

关键词：

Calcium; Calmodulin activator; Dahl rats; Hypertension; Sodium; Spontaneously hypertensive rats;

D O I：

10.1093/ajh/3.8.210

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The aim of this study was to investigate the effects of dietary calcium and sodium on blood pressure (BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneously hypertensive mice (SHM) tissues (J Clin Invest 82:276, 1988). The CaM activator was assessed by its capacity to stimulate a CaM-dependent phosphodiesterase (CaM-PDE). In Wistar rats, which were fed a high sodium diet (3.5%), BP significantly increased (P <. 01) from 106 ± 4 to 128 ± 8 mm Hg in parallel to an elevation of the CaM activator from 1.57 ± 0.14 to 2.80 ± 0.18 U. WKY, SHR, and Dahl salt-sensitive (DS/JR) and salt-resistant (DR/JR) rats were given low (0.15%) or high (2.5%) Ca diets, both with 1% sodium. In rats receiving high dietary Ca the progression of hypertension diminished and BP was lower in SHR (156 ± 4 mm Hg) and young DS/JR rats (125 ± 3 mm Hg) than in those receiving low dietary Ca (192 ± 10 and 183 ± 2 mm Hg). There was a concomitant decrease of CaM activator in these animals to levels indistinguishable from those of WKY or DR/JR rats. The activator was also found in the heart, kidneys and erythrocytes from SHM. In the presence of exogenously added CaM, lipidic extracts from the SHM heart showed augmented CaM-PDE activity relative to normotensive preparations. This difference was eliminated by trifluoperazine. Thus, the CaM activator which is increased in tissues of hypertensive rodents can be modulated along with BP by dietary Na and Ca. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：S210 / S215

页数：6

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