Human papillomavirus types in cervical biopsy specimens from Pap-smear-negative women with external genital warts

被引:8
作者
Petersen, Carsten Sand [1 ]
Lindeberg, Henning [3 ,4 ]
Thomsen, Henrik Klem [2 ]
机构
[1] Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol & Venerol, DK-1168 Copenhagen, Denmark
[2] Univ Copenhagen, Bispebjerg Hosp, Dept Pathol, DK-1168 Copenhagen, Denmark
[3] Aarhus Municipal Hosp, Royal Dent Coll, Dept Oral Pathol, Aarhus, Denmark
[4] Aarhus Municipal Hosp, Dept Pathol, Aarhus, Denmark
关键词
human papillomavirus types; cervix; genital warts; biopsy; Pap smear;
D O I
10.3109/00016349109006181
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Cervical biopsy specimens were taken from 55 Pap-smear-negative women with external genital warts in order to diagnose a concomitant cervical human papillomavirus (HPV) infection. HPV-DNA was demonstrated by in situ hybridization in 17 (31%) of the samples: HPV types 16/18 in 9, HPV types 6/11 in 5 and double infection (16/18 and 6/11) in 3. HPV-DNA was found in 10 (43%) of 23 biopsy specimens with koilocytotic atypia and in 5 (29%) of 17 specimens showing chronic inflammatory reaction, whereas only 2 (13%) of 15 women with normal cervical histology had HPV-DNA in the biopsy specimen. Overall histology and in situ hybridization indicated the presence of a cervical HPV infection in at least 30 (55%) of the 55 women examined. Colposcopic examination revealed abnormal acetowhite epithelium in 17 (74%) of 23 women with koilocytosis and/or HPV-DNA positivity. compared with 7 (32%) of 22 HPV-DNA-negative women with histology showing either chronic inflamatory changes or normal epithelium (p < 0.01). It is concluded that a cervical focus of HPV infection is frequent among Pap-smear- negative women with external genital warts.
引用
收藏
页码:69 / 71
页数:3
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