MARKED DEPENDENCE OF THE CARDIAC EFFECTS OF GALLOPAMIL ON THE EXTRACELLULAR K+-CONCENTRATION

被引:3
作者
HERZIG, S
机构
来源
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1992年 / 23卷 / 03期
关键词
D O I
10.1016/0306-3623(92)90102-P
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. In guinea-pig Langendorff hearts, the negative inotropic effect of the calcium antagonist gallopamil is shifted by 15-fold to the left, when the extracellular K+-concentration is raised from 2.7 to 8.1 mM. 2. In papillary muscles, the ability of gallopamil to shorten the action potential (AP) markedly depends on K+: 100-fold lower gallopamil concentrations were required at 10.8 mM, compared to 2.7 mM. 3. In isolated myocytes, a change in the holding potential from -90 to -70 mV displaces the gallopamil dose-response curve to block Ca2+ currents leftward by only 6-fold. 4. Tetraethylammonium (TEA, 10 mM) mimics the mitigating effect of low K+ on the gallopamil-induced AP-shortening. Hence, the K+-dependence of gallopamil may be comprised of modulation of Ca2+-channel and K+-channel blocking effects.
引用
收藏
页码:403 / 408
页数:6
相关论文
共 30 条
  • [1] INOTROPIC AND ELECTROPHYSIOLOGICAL ACTIONS OF VERAPAMIL AND D-600 IN MAMMALIAN MYOCARDIUM .1. PATTERN OF INOTROPIC EFFECTS OF RACEMIC COMPOUNDS
    BAYER, R
    HENNEKES, R
    KAUFMANN, R
    MANNHOLD, R
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1975, 290 (01) : 49 - 68
  • [2] CAMPBELL KP, 1987, J BIOL CHEM, V262, P6460
  • [3] EFFECT OF MEMBRANE-POTENTIAL CHANGES ON THE CALCIUM TRANSIENT IN SINGLE-RAT CARDIAC-MUSCLE-CELLS
    CANNELL, MB
    BERLIN, JR
    LEDERER, WJ
    [J]. SCIENCE, 1987, 238 (4832) : 1419 - 1423
  • [5] THE MECHANISM OF ACTION OF THE OPTICAL ENANTIOMERS OF VERAPAMIL AGAINST ISCHEMIA-INDUCED ARRHYTHMIAS IN THE CONSCIOUS RAT
    CURTIS, MJ
    WALKER, MJA
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1986, 89 (01) : 137 - 147
  • [6] EHARA T, 1978, J PHARMACOL EXP THER, V207, P49
  • [7] FREQUENCY-DEPENDENT EFFECTS OF VERAPAMIL ON ATRIOVENTRICULAR NODAL CONDUCTION IN MAN
    ELLENBOGEN, KA
    GERMAN, LD
    OCALLAGHAN, WG
    COLAVITA, PG
    MARCHESE, AC
    GILBERT, MR
    STRAUSS, HC
    [J]. CIRCULATION, 1985, 72 (02) : 344 - 352
  • [8] CONTRIBUTION OF 2 TYPES OF CALCIUM CURRENTS TO THE PACEMAKER POTENTIALS OF RABBIT SINO-ATRIAL NODE CELLS
    HAGIWARA, N
    IRISAWA, H
    KAMEYAMA, M
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1988, 395 : 233 - 253
  • [9] HALDIMANN C, 1963, ARCH INT PHARMACOD T, V146, P1
  • [10] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES
    HAMILL, OP
    MARTY, A
    NEHER, E
    SAKMANN, B
    SIGWORTH, FJ
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02): : 85 - 100