INCREASED MORTALITY IN FEMALE RATS AFTER BRAIN TRAUMA IS ASSOCIATED WITH LOWER FREE MG-2+

被引:15
作者
EMERSON, CS [1 ]
VINK, R [1 ]
机构
[1] JAMES COOK UNIV N QUEENSLAND,DEPT CHEM & BIOCHEM,TOWNSVILLE,QLD 4811,AUSTRALIA
关键词
MAGNESIUM; NUCLEAR MAGNETIC RESONANCE; BIOENERGETICS; BRAIN INJURY;
D O I
10.1097/00001756-199211000-00002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
MALE and female Sprague-Dawley rat siblings (200-350 g) were monitored by phosphorus magnetic resonance spectroscopy for 4 h after moderate (2.8 atmospheres) fluid-percussion-induced traumatic brain injury. Following injury, two of nine male animals died whereas 1 00 % of all female rats (n = 16) died (p < 0.01). Prior to injury, brain free magnesium concentration in males was 0.58 +/- 0.05 mM and in females 0.41 +/- 0.09. After injury, mean brain free magnesium concentration in males declined to 0.32 +/- 0.06 whereas mean brain free magnesium concentration in ventilated females (n = 6) after injury declined to 0.17 +/- 0.03 (p < 0.05). There were no significant differences between groups with respect to any other measured variables. We conclude that female rats are more susceptible to irreversible injury afterbrain trauma, and that this increased susceptibility to injury may be related to brain free magnesium levels.
引用
收藏
页码:957 / 960
页数:4
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