PROSPECTIVE-STUDY OF THE ELECTROCARDIOGRAPHIC EFFECTS OF IMIPRAMINE IN CHILDREN

被引：23

作者：

FLETCHER, SE ^{[1
]}

CASE, CL ^{[1
]}

SALLEE, FR ^{[1
]}

HAND, LD ^{[1
]}

GILLETTE, PC ^{[1
]}

机构：

[1] MED UNIV S CAROLINA, DEPT PSYCHIAT & BEHAV SCI, CHARLESTON, SC 29425 USA

来源：

JOURNAL OF PEDIATRICS | 1993年 / 122卷 / 04期

关键词：

D O I：

10.1016/S0022-3476(05)83558-9

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Because imipramine and desipramine have been implicated in sudden death in children, noninvasive electrophysiologic data were accumulated in 25 patients. Two children were excluded on the basis of resting electrocardiographic and Holter abnormalities. The remaining 23 patients received imipramine to a maximum dose of 5 mg/kg or o serum level of 150 to 250 ng/ml. Consistent but clinically insignificant resting electrocardiographic changes occurred during treatment. Ambulatory electrocardiographic monitoring may be useful when one is assessing the cardiovascular risks of imipramine therapy.

引用

页码：652 / 654

页数：3

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