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NUCLEOSOME POSITIONING AND MODIFICATION - CHROMATIN STRUCTURES THAT POTENTIATE TRANSCRIPTION

被引：165
作者：
WOLFFE, AP
机构：
[1] A. Wolffe is at the Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bethesda
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 06期
关键词：
D O I：
10.1016/0968-0004(94)90148-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of the nucleosome in the folding of DNA has often been thought of as purely a packaging one. However, the precise folding of regulatory sequences of genes around the histones within positioned nucleosomes is also important in controlling both the access of transcription factors to chromatin and the transcription process itself. This review highlights these functions by using specific examples of an active and regulatory role for positioned nucleosomes.
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页码：240 / 244
页数：5
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