NAD GLYCOHYDROLASES - A POSSIBLE FUNCTION IN CALCIUM HOMEOSTASIS

被引：18

作者：

KIM, H

JACOBSON, EL

JACOBSON, MK

机构：

[1] UNIV KENTUCKY,COLL PHARM,DIV MED CHEM & PHARMACEUT,LEXINGTON,KY 40536

[2] UNIV KENTUCKY,COLL ALLIED HLTH PROFESS,DEPT CLIN SCI,LEXINGTON,KY 40536

[3] UNIV KENTUCKY,LUCILLE P MARKEY CANC CTR,LEXINGTON,KY 40536

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1994年 / 138卷 / 1-2期

关键词：

NAD GLYCOHYDROLASES; CYCLIC ADP-RIBOSE; ADP-RIBOSE TRANSFER; CALCIUM HOMEOSTASIS; NICOTINAMIDE ADENINE DINUCLEOTIDE;

D O I：

10.1007/BF00928467

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

NAD glycohydrolases are the longest known enzymes that catalyze ADP-ribose transfer. The function of these ubiquitous, membrane-bound enzymes has been a long standing puzzle. The NAD glycohydrolases are briefly reviewed in light of the discovery by our laboratory that NAD glycohydrolases are bifunctional enzymes that can catalyze both the synthesis and hydrolysis of cyclic ADP-ribose, a putative second messenger of calcium homeostasis.

引用

页码：237 / 243

页数：7

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