INDUCTION OF REMISSION IN ACUTE LEUKEMIA WITH PREDNISONE AND INTRAVENOUS METHOTREXATE

Summary1.Daily oral prednisone (2 mg. per kilogram per day) and intermittent intravenous methotrexate (3 mg. per kilogram every 14 days) were used as initial therapy for 14 unselected children with acute lymphocytic or acute undifferentiated leukemia.2.Complete or good partial remissions were noted in every case. Bone marrow remissions (M1 rating) were achieved in 8 of 14 patients by day 14 and in all patients by day 28.3.Toxicity attributable to methotrexate was noted in only one patient, who developed mild ulcerations of the buccal mucosa. © 1968 The C. V. Mosby Company.