PREVENTION BY FREE-RADICAL SCAVENGER AD5 OF PROOXIDANT EFFECTS OF CHOLINE DEFICIENCY

被引：18

作者：

GHOSHAL, AK

RUSHMORE, TH

BUCCALDERON, P

ROBERFROID, M

FARBER, E

机构：

[1] Departments of Pathology and of Biochemistry, University of Toronto, Toronto, Ont. M5S 1A8, Medical Sciences Building

[2] Unité de Biochimie Cancerologique et Toxicologique, Université Catholique de Louvain

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1990年 / 8卷 / 01期

关键词：

AD[!sub]5[!/sub; Antioxidants; Carcinogenesis; Choline deficiency; Free radicals; Lipid peroxidation; Radicophile;

D O I：

10.1016/0891-5849(90)90137-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was designed to explore the possible preventive effects of a novel radicophile, N-p-methoxyphenylacetyl-dehydroalanine (AD5) and three other antioxidants, N, N′-diphenyl-p-phenylenediamine (DPPD), butylated hydroxyanisole (BHA) and a water-soluble analogue of vitamin E, trolox C, on the acute effects of the liver of feeding a choline-deficient (CD) diet. It has been suggested that some of the acute effects of a CD diet are related to free radicals, the generation or metabolism of which is disturbed in this acute dietary model. AD5 was found to be very effective in preventing nuclear lipid peroxidation, DNA damage and cell death induced by a CD diet but to have little effect on triglyceride accumulation ("fatty liver"). DPPD, BHA, and trolox C were ineffective. These results add strength to the hypothesis that oxygen free radicals might be an important component in the early events during carcinogenesis induced by feeding a CD diet. © 1990.

引用

页码：3 / 7

页数：5

共 21 条

[1]

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[2]

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[3]

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[4]

Ghoshal, Rushmore, Farber, Initiation of carcinogenesis by a dietary deficiency of choline in the absence of added carcinogens, Cancer Lett., 36, pp. 289-296, (1987)

[5]

Ghoshal, Roomi, Ahluwalia, Simmonds, Rushmore, Farber, Ghoshal, Glutathione and enzymes related to free radical metabolism in liver of rats fed a choline-devoid low methionine diet, Cancer Lett., 41, pp. 53-62, (1988)

[6]

Rushmore, Ghazarian, Subrahmanyan, Farber, Ghoshal, Probable free radical effects on rat liver nuclei during early hepatocarcinogenesis with a choline devoid low methionine diet, Cancer Res., 47, pp. 6731-6740, (1987)

[7]

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[8]

Chander, Lombardi, Liver cell proliferation and incidence of hepatocellular carcinomas in rats fed consecutively a choline-devoid and a choline-supplemented diet, Carcinogenesis, 9, pp. 259-263, (1988)

[9]

Rushmore, Lim, Farber, Ghoshal, Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine, Cancer Lett., 24, pp. 251-255, (1984)

[10]

Rushmore, Farber, Ghoshal, Parodi, Pala, Taningher, A choline-devoid diet, carcinogenic in the rat, induces DNA damage and repair, Carcinogenesis (Lond.), 7, pp. 1677-1680, (1986)

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