BIOCHEMICAL EFFECT OF AUROMOMYCIN ON BACTERIAL-CELLS

被引：10

作者：

SUZUKI, H

NISHIMURA, T

TANAKA, N

机构：

[1] Institute of Applied Microbiology, University of Tokyo, Tokyo

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 07期

关键词：

D O I：

10.7164/antibiotics.32.706

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The mechanism of action of auromomycin was studied with intact cells of Bacillus subtilis. The antibiotic exhibited a preferential inhibition of DNA synthesis over RNA and protein syntheses. The strand scission of cellular DNA was induced by the drug, and DNA was degraded into acid-soluble fragments. The results suggested that DNA is the chemoreceptor of auromomycin. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：706 / 710

页数：5

共 7 条

[1] COMBINED EFFECTS OF BLEOMYCIN AND SULFHYDRYL COMPOUNDS ON THERMAL DENATURATION OF DNA
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[2] MECHANISM OF ACTION OF MACROMOMYCIN - DNA STRAND SCISSION, INHIBITION OF DNA-SYNTHESIS AND MITOSIS
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[3] ON MECHANISM OF ACTION OF BLEOMYCIN - SCISSION OF DNA STRANDS IN VITRO AND IN VIVO
SUZUKI, H
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[4] SUZUKI H, 1979, CANCER RES, V39
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[6] EFFECTS OF BLEOMYCIN A2 DEOXYRIBONUCLEASE, DNA POLYMERASE AND LIGASE REACTIONS
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[J]. JOURNAL OF ANTIBIOTICS, 1971, 24 (03) : 178 - &
[7] STUDIES ON AUROMOMYCIN
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NAOI, N
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TAKEUCHI, T
UMEZAWA, H
[J]. JOURNAL OF ANTIBIOTICS, 1979, 32 (04) : 330 - 339

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