CONCENTRATION OF DICLOXACILLIN AND BENZYLPENICILLIN IN FRACTURE HEMATOMA

Prophylaxis [antibacterial] with loading doses of dicloxacillin (3 patients) and benzylpenicillin (5 patients) was used pre-operatively for malleolar fractures treated in a standardized manner. Post-operatively, the same dose was given every 6 h for 48 h. The concentration of antibiotics was measured in serum before and after operation and 6 h after the 1st infusion. Samples from the hematoma were taken during operation and from the drainage collected during 24 h. Satisfactory concentrations were found in serum pre- and post-operatively and in the hematoma.