THE SUPPRESSION OF OLFACTORY BULBECTOMY-INDUCED MURICIDE BY ANTIDEPRESSANTS AND ANTIHISTAMINES VIA HISTAMINE H1 RECEPTOR BLOCKING

被引：22

作者：

NOGUCHI, S ^{[1
]}

INUKAI, T ^{[1
]}

KUNO, T ^{[1
]}

TANAKA, C ^{[1
]}

机构：

[1] KOBE UNIV,SCH MED,DEPT PHARMACOL,KOBE 650,JAPAN

来源：

PHYSIOLOGY & BEHAVIOR | 1992年 / 51卷 / 06期

关键词：

MURICIDE; OLFACTORY BULBECTOMY; ANTIDEPRESSANTS; ANTIHISTAMINES; HISTAMINE H1 RECEPTOR;

D O I：

10.1016/0031-9384(92)90297-F

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The effects of antidepressants [(+)-oxaprotiline, (-)-oxaprotiline, imipramine, maprotiline, and trazodone] and antihistamines (mepyramine, dimethindene, ketotifen, methapyrilene, and antazoline) on muricidal behaviour in olfactory bulbectomized rats were investigated. All drugs except for dimethindene, which only minimally passes across the blood-brain barrier, suppressed muricide. The drugs which have high affinity for histamine H1 receptor showed potent suppressive effect on muricide. It is suggested that the central histaminergic system is involved via H1 receptors in the expression of muricide in olfactory bulbectomized rats.

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收藏

页码：1123 / 1127

页数：5

相关论文

共 19 条

[1]

BARNETT A, 1969, INT J NEUROPHARMACOL, V8, P73

[2] CHARACTERIZATION OF THE BINDING OF H-3-SCH 23390, A SELECTIVE D-1 RECEPTOR ANTAGONIST LIGAND, IN RAT STRIATUM [J].

BILLARD, W ;

RUPERTO, V ;

CROSBY, G ;

IORIO, LC ;

BARNETT, A .

LIFE SCIENCES, 1984, 35 (18) :1885-1893

[3] [H-3]8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)TETRALIN BINDING TO PRESYNAPTIC AND POSTSYNAPTIC 5-HYDROXYTRYPTAMINE SITES IN VARIOUS REGIONS OF THE RAT-BRAIN [J].

HALL, MD ;

ELMESTIKAWY, S ;

EMERIT, MB ;

PICHAT, L ;

HAMON, M ;

GOZLAN, H .

JOURNAL OF NEUROCHEMISTRY, 1985, 44 (06) :1685-1696

[4] (H-3-)GBR-12935 BINDING-SITES IN HUMAN STRIATAL MEMBRANES - BINDING CHARACTERISTICS AND CHANGES IN PARKINSONIANS AND SCHIZOPHRENICS [J].

HIRAI, M ;

KITAMURA, N ;

HASHIMOTO, T ;

NAKAI, T ;

MITA, T ;

SHIRAKAWA, O ;

YAMADORI, T ;

AMANO, T ;

NOGUCHIKUNO, SA ;

TANAKA, C .

JAPANESE JOURNAL OF PHARMACOLOGY, 1988, 47 (03) :237-243

[5] ALPHA-1-ADRENERGIC AND BETA-ADRENERGIC AND MUSCARINIC CHOLINERGIC RECEPTORS IN GUINEA-PIG NASAL-MUCOSA [J].

ISHIBE, T ;

KUNO, T ;

TANAKA, C .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 106 (01) :107-112

[6] EFFECTS OF ANTIDEPRESSANT DRUGS ON THE BEHAVIOR OF OLFACTORY BULBECTOMIZED AND SHAM-OPERATED RATS [J].

JESBERGER, JA ;

RICHARDSON, JS .

BEHAVIORAL NEUROSCIENCE, 1986, 100 (02) :256-&

[7]

JOSHI NK, 1968, INDIAN J MED SCI, V21, P804

[8] ANTIMUSCARINIC EFFECTS OF ANTIHISTAMINES - QUANTITATIVE-EVALUATION BY RECEPTOR-BINDING ASSAY [J].

KUBO, N ;

SHIRAKAWA, O ;

KUNO, T ;

TANAKA, C .

JAPANESE JOURNAL OF PHARMACOLOGY, 1987, 43 (03) :277-282

[9] NOREPINEPHRINE NEURONAL UPTAKE BINDING-SITES IN RAT-BRAIN MEMBRANES LABELED WITH [DESIPRAMINE-H-3 [J].

LEE, CM ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (08) :5250-5254

[10] SPIPERONE - LIGAND OF CHOICE FOR NEUROLEPTIC RECEPTORS .1. KINETICS AND CHARACTERISTICS OF INVITRO BINDING [J].

LEYSEN, JE ;

GOMMEREN, W ;

LADURON, PM .

BIOCHEMICAL PHARMACOLOGY, 1978, 27 (03) :307-316