EVIDENCE FOR AN ENZYMATIC DEFECT IN THE 4-HYDROXYLATION OF DEBRISOQUINE BY HUMAN-LIVER

被引：111

作者：

DAVIES, DS

KAHN, GC

MURRAY, S

BRODIE, MJ

BOOBIS, AR

机构：

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1981年 / 11卷 / 01期

关键词：

D O I：

10.1111/j.1365-2125.1981.tb01108.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

收藏

页码：89 / 91

页数：3

相关论文

共 11 条

[1] PHARMACOGENETIC COVARIATION OF DEFECTIVE N-OXIDATION OF SPARTEINE AND 4-HYDROXYLATION OF DEBRISOQUINE
BERTILSSON, L
DENGLER, HJ
EICHELBAUM, M
SCHULZ, HU
[J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 17 (02) : 153 - 155
[2] MONO-OXYGENASE ACTIVITY OF HUMAN-LIVER IN MICROSOMAL FRACTIONS OF NEEDLE-BIOPSY SPECIMENS
BOOBIS, AR
BRODIE, MJ
KAHN, GC
FLETCHER, DR
SAUNDERS, JH
DAVIES, DS
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 9 (01) : 11 - 19
[3] BOOBIS AR, 1979, BRIT J PHARMACOL, V66, pP428
[4] EICHELBAUM M, 1975, THESIS U BONN W GERM
[5] DEFICIENT METABOLISM OF DEBRISOQUINE AND SPARTEINE
INABA, T
OTTON, SV
KALOW, W
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1980, 27 (04) : 547 - 549
[6] POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN
MAHGOUB, A
IDLE, JR
DRING, LG
LANCASTER, R
SMITH, RL
[J]. LANCET, 1977, 2 (8038) : 584 - 586
[7] DETERMINATION OF DEBRISOQUIN AND ITS 4-HYDROXY METABOLITE IN PLASMA BY GAS CHROMATOGRAPHY MASS SPECTROMETRY
MALCOLM, SL
MARTEN, TR
[J]. ANALYTICAL CHEMISTRY, 1976, 48 (06) : 807 - 809
[8] MITCHELL JR, 1970, J PHARMACOL EXP THER, V172, P108
[9] Ritchie J. C., 1980, ENV CHEM ENZYME FUNC, P219
[10] POLYMORPHISM OF CARBON OXIDATION OF DRUGS AND CLINICAL IMPLICATIONS
SLOAN, TP
MAHGOUB, A
LANCASTER, R
IDLE, JR
SMITH, RL
[J]. BRITISH MEDICAL JOURNAL, 1978, 2 (6138) : 655 - 657