ADRENERGIC INHIBITION OF INSULIN-SECRETION INVOLVES PERTUSSIS TOXIN-SENSITIVE AND TOXIN-INSENSITIVE MECHANISMS

被引：7

作者：

HILLAIREBUYS, D ^{[1
]}

GROSS, R ^{[1
]}

ROYE, M ^{[1
]}

RIBES, G ^{[1
]}

LOUBATIERESMARIANI, MM ^{[1
]}

机构：

[1] CNRS,FAC MED,PHARMACOL LAB,URA 599,F-34033 MONTPELLIER,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 218卷 / 2-3期

关键词：

PANCREAS; (ISOLATED; RAT); PERTUSSIS TOXIN; INSULIN SECRETION; ADRENALINE; ALPHA-2-ADRENOCEPTORS;

D O I：

10.1016/0014-2999(92)90193-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We studied the involvement of Bordetella pertussis toxin (PTX)-sensitive G proteins in the inhibition by adrenaline of insulin secretion from the isolated rat pancreas. The -90% inhibition induced by adrenaline (0.05-mu-M) was partially abolished after in vivo PTX pretreatment. The residual inhibitory effect of adrenaline in PTX-pretreated rats was suppressed by the alpha-2-adrenoceptor antagonist, yohimbine, but was not modified by the alpha-1-adrenoceptor antagonist, prazosin. Thus, the alpha-2-inhibitory effect of adrenaline on B-cells is mediated by both PTX-sensitive and PTX-insensitive mechanisms.

引用

页码：359 / 362

页数：4

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