INDUCTION OF AROMATASE IN STROMAL-VASCULAR CELLS FROM HUMAN BREAST ADIPOSE-TISSUE DEPENDS ON CORTISOL AND GROWTH-FACTORS

被引：18

作者：

SCHMIDT, M ^{[1
]}

LOFFLER, G ^{[1
]}

机构：

[1] UNIV REGENSBURG, INST BIOCHEM GENET & MICROBIOL, D-93040 REGENSBURG, GERMANY

来源：

FEBS LETTERS | 1994年 / 341卷 / 2-3期

关键词：

AROMATASE; CORTISOL; PDGF; BFGF; BREAST ADIPOSE TISSUE (HUMAN);

D O I：

10.1016/0014-5793(94)80452-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of aromatase (estrogen synthase) activity of cultured stromal vascular cells from human breast adipose tissue by cortisol, db-cAMP and growth factors was studied in a serum-free culture system. While PDGF-BB alone inhibited the effect of db-cAMP on aromatase induction, it stimulated aromatase activity in the presence of cortisol with or without db-cAMP. In the presence of 1 muM insulin consistently higher aromatase activities were found as compared to 1 nM insulin. In contrast to PDGF-BB, bFGF led to an increase of aromatase activity only in the presence of both cortisol and db-cAMP.

引用

页码：177 / 181

页数：5

共 25 条

[1] AROMATIZATION OF ANDROSTENEDIONE BY HUMAN ADIPOSE-TISSUE STROMAL CELLS IN MONOLAYER-CULTURE [J].

ACKERMAN, GE ;

SMITH, ME ;

MENDELSON, CR ;

MACDONALD, PC ;

SIMPSON, ER .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (02) :412-417

[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3]

CLARKE R, 1991, NUCLEAR HORMONE RECE, P297

[4] EFFECTS OF AGING AND OBESITY ON AROMATASE-ACTIVITY OF HUMAN ADIPOSE-CELLS [J].

CLELAND, WH ;

MENDELSON, CR ;

SIMPSON, ER .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (01) :174-177

[5] CONVERSION OF 19-OXO[2-BETA-2H]ANDROGENS INTO ESTROGENS BY HUMAN PLACENTAL AROMATASE - AN UNEXPECTED STEREOCHEMICAL OUTCOME [J].

COLE, PA ;

ROBINSON, CH .

BIOCHEMICAL JOURNAL, 1990, 268 (03) :553-561

[6] REGULATION OF PROLIFERATION, INVASION AND GROWTH-FACTOR SYNTHESIS IN BREAST-CANCER BY STEROIDS [J].

DICKSON, RB ;

THOMPSON, EW ;

LIPPMAN, ME .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1990, 37 (03) :305-316

[7] ESTROGENIC REGULATION OF GROWTH AND POLYPEPTIDE GROWTH-FACTOR SECRETION IN HUMAN-BREAST CARCINOMA [J].

DICKSON, RB ;

LIPPMAN, ME .

ENDOCRINE REVIEWS, 1987, 8 (01) :29-43

[8] SOURCE OF ESTROGEN PRODUCTION IN POSTMENOPAUSAL WOMEN [J].

GRODIN, JM ;

SIITERI, PK ;

MACDONALD, PC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1973, 36 (02) :207-214

[9] GROWTH-REGULATION OF HUMAN-BREAST CARCINOMA OCCURS THROUGH REGULATED GROWTH-FACTOR SECRETION [J].

LIPPMAN, ME ;

DICKSON, RB ;

GELMANN, EP ;

ROSEN, N ;

KNABBE, C ;

BATES, S ;

BRONZERT, D ;

HUFF, K ;

KASID, A .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, 35 (01) :1-16

[10]

LIPPMAN ME, 1989, RECENT PROG HORM RES, V45, P383

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