INTRAVASCULAR METABOLISM OF DIFFERENT FATTY-ACIDS DURING LIPID INFUSION IN MAN

被引：17

作者：

SIDEROVA, VS ^{[1
]}

CARPENTIER, YA ^{[1
]}

DAHLAN, W ^{[1
]}

RICHELLE, M ^{[1
]}

机构：

[1] UNIV LIBRE BRUXELLES,L DELOYERS LAB EXPTL SURG,B-1070 BRUSSELS,BELGIUM

来源：

CLINICAL NUTRITION | 1993年 / 12卷 / 06期

关键词：

D O I：

10.1016/0261-5614(93)90028-3

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The differential intravascular metabolism of individual fatty acids contained in triacylglycerol-rich particles was studied by infusing 6 normal subjects for 5 h with a conventional soy-based emulsion and an experimental olive oil-based emulsion. Both emulsions contained similar amounts of palmitate (11%) and stearate (3-4%) but the former was quite rich in linoleate (54%) and alpha-linolenate (7%), while the latter was rich in oleate (69%). During hydrolysis of circulating triacylglycerols by endothelial lipases, the associated rise of non-esterified fatty acids (FFA) in plasma represents the balance between fatty acid release and tissue uptake. Plasma levels of triacylglycerols and FFA increased about 3 fold and total body fat oxidation was raised to similar values with both emulsions. Fatty acid pattern quickly changed in plasma triacylglycerols to resemble the composition of emulsion particles, with an exception for palmitate which increased markedly more, suggesting a high level of hepatic re-esterification and re-appearance in nascent very low density lipoprotein triglycerides (VLDL-TG) secreted into the circulation. In plasma FFA, stearate and palmitate increased more and alpha-linolenate much less than expected from their content in the emulsion, indicating probably low tissue uptake for the former ones but avid removal for the latter.

引用

页码：329 / 336

页数：8

共 29 条

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