OXIDATION OF PYRIDINE-NUCLEOTIDES AND DEPLETION OF ATP AND ADP DURING CALCIUM-INDUCED AND INORGANIC PHOSPHATE-INDUCED MITOCHONDRIAL PERMEABILITY TRANSITION

被引：13

作者：

SAVAGE, MK

REED, DJ

机构：

[1] Department of Biochemistry and Biophysics, Agricultural and Life Sciences 2011, Oregon State University, Corvallis

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1636

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have examined the pyridine and adenine nucleotide status during calcium- and inorganic phosphate-induced permeability transition. Calcium- and inorganic phosphate-induced permeability transition is accompanied by the rapid oxidation of pyridine nucleotides and depletion of ATP and ADP with conversion to AMP. The addition of cyclosporin A, a potent inhibitor of the permeability transition prevented the oxidation of pyridine nucleotides and depletion of ATP and ADP. (C) 1994 Academic Press, Inc.

引用

页码：1615 / 1620

页数：6

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