ENANTIOSELECTIVE SYNTHESIS OF (-)-TRICHODIENE

被引：37

作者：

GILBERT, JC

SELLIAH, RD

机构：

[1] Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 23期

关键词：

D O I：

10.1021/jo00075a020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective synthesis of trichodiene 1 has been accomplished. The key bond between the vicinal quaternary centers is formed by way of an Ireland-Claisen rearrangement of the ketene silyl acetal 24. The rearrangement occurs with complete facial selectivity and excellent diastereoselectivity to give an advanced intermediate that is directly converted to ent-trichodiene, (-)-1.

引用

页码：6255 / 6265

页数：11

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