CHANGES IN THE PRODUCTION OF NITRIC-OXIDE AND SUPEROXIDE BY INFLAMMATORY CELLS IN LIVER-CIRRHOSIS

被引：11

作者：

MASINI, E ^{[1
]}

MUGNAI, L ^{[1
]}

FOSCHI, M ^{[1
]}

LAFFI, G ^{[1
]}

GENTILINI, P ^{[1
]}

MANNAIONI, PF ^{[1
]}

机构：

[1] UNIV FLORENCE,SCH MED,MED CLIN 2,I-50134 FLORENCE,ITALY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1995年 / 107卷 / 1-3期

关键词：

NEUTROPHILS; MONOCYTES SUPEROXIDE; NITRIC OXIDE; LIVER CIRRHOSIS;

D O I：

10.1159/000236975

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Superoxide (O-2(-)) and nitric oxide (NO) production by polymorphonuclear leukocyte (PMNs) and monocytes in patients with liver cirrhosis were evaluated. PMNs obtained from cirrhotic patients were less effective than those from controls in producing O-2(-) after stimulation with opsonized zymosan, while they were more effective in producing NO, as shown by the inhibition of platelet aggregation and by the increase in cGMP content. NO synthase activity was higher in leukocytes from cirrhotic patients than in controls. A correlation was found between the cardiac index and the observed changes in the inflammatory cells.

引用

页码：197 / 198

页数：2