CONTROL AND ACTIVITY OF TYPE-1 SERINE/THREONINE PROTEIN PHOSPHATASE DURING THE CELL-CYCLE

被引：29

作者：

LUDLOW, JW ^{[1
]}

NELSON, DA ^{[1
]}

机构：

[1] UNIV ROCHESTER, CTR CANC, DIV DEV THERAPEUT, ROCHESTER, NY 14642 USA

来源：

SEMINARS IN CANCER BIOLOGY | 1995年 / 6卷 / 04期

关键词：

SERINE/THREONINE PHOSPHATASE; PP1; CELL CYCLE; RETINOBLASTOMA PROTEIN; DEPHOSPHORYLATION;

D O I：

10.1006/scbi.1995.0026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The first part of this discourse will serve as a compendium of selected aspects of PP1 activity and control during the cell cycle. The latter sections will focus on the mammalian cell cycle dependent activity of PP1 on the negative growth regulatory product of the retinoblastoma susceptibility gene, pRB. The purpose here is to suggest one possible mechanism to explain how this phosphatase can effect cell cycle progression. An argument is made for PP1 playing an indirect role in regulating cell cycle progression by modulating the growth suppressive activity of pRB.

引用

页码：195 / 202

页数：8

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