STIMULATION OF RENIN SECRETION FROM THE INTACT KIDNEY AND FROM ISOLATED GLOMERULI BY THE CALCIUM IONOPHORE-A23187

被引：26

作者：

HARADA, E ^{[1
]}

LESTER, GE ^{[1
]}

RUBIN, RP ^{[1
]}

机构：

[1] VIRGINIA COMMONWEALTH UNIV, DEPT PHARMACOL, RICHMOND, VA 23298 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 583卷 / 01期

关键词：

(Kidney); Ca[!sup]2+[!/sup] transport; Ionophore A23187; Renin secretion;

D O I：

10.1016/0304-4165(79)90305-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ionophore A23187 evoked a dose-dependent release of renin from the isolated perfused cat kidney, which was inhibited by calcium deprivation and adrenergic blockade. The latter finding indicates that the effects of A23187 on the intact kidney are mediated mainly by catecholamine release from sympathetic nerve endings. Ionophore also elicited a concentration-dependent enhancement of renin secretion from a pure preparation of glomeruli isolated from cat kidney; this stimulation was still manifest when the glomeruli were superfused with a calcium-free solution. These findings indicate that A23187 evokes renin secretion from juxtaglomerular cells by mobilizing cellular calcium and support the view that an increase in intracellular calcium is intimately involved in the mechanism of renin secretion. © 1979.

引用

页码：20 / 27

页数：8

共 19 条

[1] STUDIES ON MECHANISM OF RENIN RELEASE FROM ISOLATED SUPER-FUSED RAT GLOMERULI - EFFECTS OF CALCIUM, CALCIUM IONOPHORE AND LANTHANUM [J].

BAUMBACH, L ;

LEYSSAC, PP .

JOURNAL OF PHYSIOLOGY-LONDON, 1977, 273 (03) :745-764

[2]

Berridge M J, 1975, Adv Cyclic Nucleotide Res, V6, P1

[3] GLUCAGON-RELEASE FROM RAT PANCREATIC-ISLETS - COMBINED MORPHOLOGICAL AND FUNCTIONAL APPROACH [J].

CARPENTIER, JL ;

MALAISSELAGAE, F ;

MULLER, WA ;

ORCI, L .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (05) :1174-1182

[4]

CHEN DS, 1976, P SOC EXP BIOL MED, V152, P565, DOI 10.3181/00379727-152-39441

[5] INNERVATION OF THE RENAL BLOOD VESSELS IN THE CAT [J].

CHRISTENSEN, K ;

LEWIS, E ;

KUNTZ, A .

JOURNAL OF COMPARATIVE NEUROLOGY, 1951, 95 (03) :373-385

[6] MECHANISMS REGULATING RENIN RELEASE [J].

DAVIS, JO ;

FREEMAN, RH .

PHYSIOLOGICAL REVIEWS, 1976, 56 (01) :1-56

[7] PLATELET SECRETION INDUCED BY DIVALENT-CATION IONOPHORES [J].

FEINMAN, RD ;

DETWILER, TC .

NATURE, 1974, 249 (5453) :172-173

[8]

FLYNN M, 1977, P ROY SOC LOND B BIO, V199, P199

[9] STIMULATION OF RENIN SECRETION AND CALCIUM EFFLUX FROM ISOLATED PERFUSED CAT KIDNEY BY NORADRENALINE AFTER PROLONGED CALCIUM DEPRIVATION [J].

HARADA, E ;

RUBIN, RP .

JOURNAL OF PHYSIOLOGY-LONDON, 1978, 274 (JAN) :367-379

[10]

KARL RC, 1975, J BIOL CHEM, V250, P4575

← 1 2 →