EFFECT OF MAZINDOL ON BRAIN DOPAMINE TURNOVER IN SPIPERONE-TREATED RATS

被引：14

作者：

FULLER, RW

SNODDY, HD

机构：

[1] The Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana

来源：

JOURNAL OF NEURAL TRANSMISSION | 1979年 / 44卷 / 1-2期

关键词：

D O I：

10.1007/BF01252698

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mazindol, an anorexic drug, caused a large increase in brain 3, 4-dihydroxyphenylacetic acid (DOPAC) concentration in spiperone-pretreated rats. The increase was dose-related over a 1-10 mg/kg dose range of mazindol and was maximum within 1 hour after mazindol injection into rats pretreated 1 hour previously with spiperone. In spiperone-pretreated rats, mazindol accelerated the disappearance of dopamine after inhibition of dopamine synthesis by α-methyltyrosine. Mazindol apparently resembles amfonelic acid, methylphenidate, and cocaine in facilitating the impulse-mediated release of dopamine. © 1979 Springer-Verlag.

引用

页码：13 / 19

页数：7

共 16 条

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