ASSOCIATION OF HEPATITIS-B E-ANTIGEN (HBEAG) DETERMINANTS WITH THE CORE OF DANE PARTICLES

被引：24

作者：

NEURATH, AR

STRICK, N

机构：

来源：

JOURNAL OF GENERAL VIROLOGY | 1979年 / 42卷 / MAR期

关键词：

D O I：

10.1099/0022-1317-42-3-645

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Immunoprecipitates obtained by reacting Dane particle cores with human antibodies to hepatitis B core antigen (HBcAg) were chromatographed on columns of Sepharose 4B CL using 3 M-NaSCN as eluant. An antigen having the size and immunological specificity of monomeric e-antigen (HBeAg) was separated from HBcAg by this method. Antisera from animals immunized with HBcAg or HBeAg reacted not only with the antigen used for immunization but also with HBeAg and HBcAg, respectively. This indicates that HBeAg determinants are associated with the core of Dane particles.

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页码：645 / 649

页数：5

相关论文

共 27 条

[1] TYPE B-HEPATITIS - INFECTIVITY OF BLOOD POSITIVE FOR E ANTIGEN AND DNA-POLYMERASE AFTER ACCIDENTAL NEEDLESTICK EXPOSURE [J].

ALTER, HJ ;

SEEFF, LB ;

KAPLAN, PM ;

MCAULIFFE, VJ ;

WRIGHT, EC ;

GERIN, JL ;

PURCELL, RH ;

HOLLAND, PV ;

ZIMMERMAN, HJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (17) :909-913

[2] LOCALIZATION OF E-ANTIGEN IN NUCLEI OF HEPATOCYTES IN HBSAG-POSITIVE LIVER-DISEASES [J].

ARNOLD, W ;

NIELSEN, JO ;

HARDT, F ;

MEYERZUMBUSCHENFELDE, KH .

GUT, 1977, 18 (12) :994-996

[3] E-ANTIGEN AND VERTICAL TRANSMISSION OF HEPATITIS-B SURFACE-ANTIGEN [J].

BEASLEY, RP ;

TREPO, C ;

STEVENS, CE ;

SZMUNESS, W .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1977, 105 (02) :94-98

[4] ANTIBODY TO INFLUENZA-VIRUS MATRIX PROTEIN DETECTS A COMMON ANTIGEN ON SURFACE OF CELLS INFECTED WITH TYPE-A INFLUENZA-VIRUSES [J].

BIDDISON, WE ;

DOHERTY, PC ;

WEBSTER, RG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 146 (03) :690-697

[5] IMMUNOLOGICAL RECOGNITION OF INFLUENZA VIRUS-INFECTED CELLS .2. EXPRESSION OF INFLUENZA A MATRIX PROTEIN ON INFECTED CELL-SURFACE AND ITS ROLE IN RECOGNITION BY CROSS-REACTIVE CYTOTOXIC-T CELLS [J].

BRACIALE, TJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1977, 146 (03) :673-689

[6] IMMUNOCHEMICAL AND MORPHOLOGICAL-STUDIES OF HEPATITIS-B CORE ANTIGEN ISOLATED FROM NUCLEI OF HEPATOCYTES [J].

BUDKOWSKA, A .

JOURNAL OF INFECTIOUS DISEASES, 1977, 135 (03) :463-467

[7] BIOCHEMICAL AND BIOPHYSICAL PROPERTIES OF HEPATITIS B CORE PARTICLES DERIVED FROM DANE PARTICLES AND INFECTED HEPATOCYTES [J].

FIELDS, HA ;

HOLLINGER, FB ;

DESMYTER, J ;

MELNICK, JL ;

DREESMAN, GR .

INTERVIROLOGY, 1977, 8 (06) :336-350

[8] ANTIGENS OF HEPATITIS-B VIRUS - FAILURE TO DETECT HBEAG ON SURFACES OF HBSAG FORMS [J].

GERIN, JL ;

SHIH, JWK ;

MCAULIFFE, VJ ;

PURCELL, RH .

JOURNAL OF GENERAL VIROLOGY, 1978, 38 (MAR) :561-566

[9]

HOWARD CR, 1976, PROG MED VIROL, V22, P36

[10]

HUANG SN, LABORATORY INVESTIGA