INHIBITION OF BACLOFEN-INDUCED HYPOTHERMIA IN MICE BY THE NOVEL GABA-B ANTAGONIST CGP 35348

This study shows that the selective GABA(B) antagonist CGP 35348 had no effect on body temperature in mice in doses up to 300 mg/kg i.p. However, the highest dose abolished the hypothermia induced by the GABA(B) agonist baclofen (10 mg/kg i.p.) but not that produced by the GABA-mimetic progabide (200 mg/kg i.p.); the benzodiazepine agonist loprazolam (3 mg/kg i.p.); the alpha-2-agonist UK 14,304 (1 mg/kg i.p.) nor the mu-opioid agonist morphine (30 mg/kg i.p.). These findings, showing selective antagonism of GABA(B) receptors by CGP 35348, confirm that this compound may be a valuable tool for exploration of GABA(B) receptor function in vivo.