ACTIVATION OF 5-HT3 RECEPTOR BY 1-PHENYLBIGUANIDE INCREASES DOPAMINE RELEASE IN THE RAT NUCLEUS-ACCUMBENS

被引：192

作者：

CHEN, J

VANPRAAG, HM

GARDNER, EL

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT,BEHAV PHARMACOL LAB,BRONX,NY 10461

来源：

BRAIN RESEARCH | 1991年 / 543卷 / 02期

关键词：

SEROTONIN-3; RECEPTOR; 1-PHENYLBIGUANIDE; ZACOPRIDE; GR38032F; DOPAMINE; NUCLEUS ACCUMBENS; MICRODIALYSIS;

D O I：

10.1016/0006-8993(91)90050-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The serotonin-3 (5-HT3) agonist 1-phenylbiguanide (0.1-1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT3 antagonists zacopride and GR38032F (1 mM in perfusate). Similar effects were observed in 5-HT-denervated rats. These findings suggest that there is a potent modulation of dopamine (DA) release in the nucleus accumbens mediated via 5-HT3 receptors, which appear to be located presynaptically on DA terminals of the mesolimbic DA pathway.

引用

页码：354 / 357

页数：4

共 20 条

[1] [H-3] ZACOPRIDE - LIGAND FOR THE IDENTIFICATION OF 5-HT3 RECOGNITION SITES [J].