SULFATION OF THE FLAVONOIDS QUERCETIN AND CATECHIN BY RAT-LIVER

被引：33

作者：

SHALI, NA ^{[1
]}

CURTIS, CG ^{[1
]}

POWELL, GM ^{[1
]}

ROY, AB ^{[1
]}

机构：

[1] AUSTRALIAN NATL UNIV, JOHN CURTIN SCH MED RES, PROT CHEM GRP, CANBERRA, ACT 2601, AUSTRALIA

来源：

XENOBIOTICA | 1991年 / 21卷 / 07期

关键词：

D O I：

10.3109/00498259109039528

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The isolated perfused rat liver forms three sulphated metabolites from each of the flavonoids, quercetin and catechin: these are secreted into the bile and the perfusate. 2. Quercetin gives two double conjugates, containing sulphate and glucuronic acid, and one sulphate: catechin gives one such double conjugate and two sulphates. 3. This sulphation is not inhibited by 60-mu-M 2,6-dichloro-4-nitrophenol which almost completely inhibits the sulphation of harmol in this perfused liver system. 4. The sulphation of harmol by the perfused liver is not inhibited by the flavonoids. 5. Unfractionated sulphotransferases from mt liver catalyse sulphate conjugation of quercetin and catechin in vitro by a reaction inhibited by pentachlorophenol or dichloro-nitrophenol; the flavonoids inhibit the sulphation of 4-nitrophenol by this system. 6. The results with the two systems are discussed and shown to be compatible.

引用

页码：881 / 893

页数：13

共 31 条

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