DIASTEREOSELECTIVE SYNTHESIS OF CYCLOPROPYL PHENYLALANINES AND THEIR INCORPORATION INTO DIPEPTIDES

被引：21

作者：

CAMPBELL, MM ^{[1
]}

HORWELL, DC ^{[1
]}

MAHON, MF ^{[1
]}

PRITCHARD, MC ^{[1
]}

WALFORD, SP ^{[1
]}

机构：

[1] PARKE DAVIS NEUROSCI RES UNIT,CAMBRIDGE CB2 2QB,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81250-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2,3-Methanophenylalanine methyl esters have been prepared diastereoselectively and incorporated into dipeptoid analogues of the tetrapeptide cholecystokinin, CCK(30-33). (Z)-(1S, 3S, 6S)- and (E)-(1R, 3S, 6S)-7(H)-6-isopropyl-5-methoxy-1-phenyl-4,7-diazaspiro[2,5]oct-4-en-8-ones (12a,b) have been hydrolysed to afford the (Z)- and (E)- delPhe-Val-OMe dipeptides (16a,b), respectively.

引用

页码：667 / 670

页数：4

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