GENETIC-POLYMORPHISM OF OROSOMUCOID (ORM) IN POPULATIONS OF THE UNITED-KINGDOM, INDIAN SUBCONTINENT, AND CAMBODIA

被引：6

作者：

MASTANA, SS

JAYASEKARA, R

FISHER, P

SOKOL, RJ

PAPIHA, SS

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT HUMAN GENET,19-20 CLAREMONT PL,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND

[2] LOUGHBOROUGH UNIV TECHNOL,DEPT HUMAN SCI,HUMAN GENET LAB,LOUGHBOROUGH LE11 3TU,LEICS,ENGLAND

[3] UNIV COLOMBO,FAC MED,HUMAN GENET UNIT,COLOMBO,SRI LANKA

[4] REG BLOOD TRANSFUS CTR,SHEFFIELD,ENGLAND

来源：

JAPANESE JOURNAL OF HUMAN GENETICS | 1993年 / 38卷 / 03期

关键词：

POLYMORPHISM; OROSOMUCOID; ETHNIC GROUPS; UNITED-KINGDOM; INDIA; CAMBODIA; SRI-LANKA;

D O I：

10.1007/BF01874139

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genetic variation of the human serum orosomucoid (ORM) was investigated by isoelectric focusing (IEF) followed by immunofixation in 15 different populations from East Midlands (United Kingdom), India, Sri Lanka, and Cambodia. Statistically significant differences were observed between various Asiatic and British populations, however differences within Asiatic and European populations were minor. The distribution of ORM1 alleles in populations investigated to date suggests an interesting east-west geographical cline. There is a suggestion that present day wide polymorphism at the ORM1 locus may be influenced by selection.

引用

页码：289 / 296

页数：8

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