PREDICTING PROTEIN CRYSTALLIZATION FROM A DILUTE-SOLUTION PROPERTY

被引:609
作者
GEORGE, A
WILSON, WW
机构
来源
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY | 1994年 / 50卷
关键词
D O I
10.1107/S0907444994001216
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A dilute solution parameter obtained from static light-scattering measurements is proposed as a predictor for protein crystallization experiments. The osmotic second virial coefficients, B22, have been measured for a variety of proteins in solvents that are known to promote crystallization and the values for B22 were found to lie within a fairly narrow range which we refer to as a crystallization slot. Solution conditions which were known not to favor crystallization of the proteins resulted in B22 values well outside the crystallization slot.
引用
收藏
页码:361 / 365
页数:5
相关论文
共 22 条
  • [1] Berne B. J., 1976, DOVER BOOKS PHYS SER
  • [2] CARTER C W JR, 1990, Methods (Orlando), V1, P12, DOI 10.1016/S1046-2023(05)80142-2
  • [3] STATISTICAL DESIGN OF EXPERIMENTS FOR PROTEIN CRYSTAL-GROWTH AND THE USE OF A PRECRYSTALLIZATION ASSAY
    CARTER, CW
    BALDWIN, ET
    FRICK, L
    [J]. JOURNAL OF CRYSTAL GROWTH, 1988, 90 (1-3) : 60 - 73
  • [4] CARTER D, 1992, COMMUNICATION
  • [5] CASEY G, 1992, J CRYST GROWTH, V122, P85
  • [6] CHU B, 1983, APPLICATION LASER LI, P53
  • [7] FEHER G, 1985, METHOD ENZYMOL, V114, P77
  • [8] GAIER JR, 1981, J BIOL CHEM, V256, P1417
  • [9] FORMATION DYNAMICS OF PROTEIN PRECRYSTALLIZATION FRACTAL CLUSTERS
    GEORGALIS, Y
    ZOUNI, A
    EBERSTEIN, W
    SAENGER, W
    [J]. JOURNAL OF CRYSTAL GROWTH, 1993, 126 (2-3) : 245 - 260
  • [10] CHARACTERIZATION OF PRECRYSTALLIZATION AGGREGATION OF CANAVALIN BY DYNAMIC LIGHT-SCATTERING
    KADIMA, W
    MCPHERSON, A
    DUNN, MF
    JURNAK, FA
    [J]. BIOPHYSICAL JOURNAL, 1990, 57 (01) : 125 - 132