Ribonucleotide reductases: Radical enzymes with suicidal tendencies

被引：189

作者：

Stubbe, JA ^{[1
]}

vanderDonk, WA ^{[1
]}

机构：

[1] MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA

来源：

CHEMISTRY & BIOLOGY | 1995年 / 2卷 / 12期

关键词：

D O I：

10.1016/1074-5521(95)90084-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribonucletide reductases catalyze a key step in DNA biosynthesis, using a diverse array of unprecedented metallo-cofactors to generate a transient protein radical that initiates nucleotide reduction. The new understanding of the chemistry and biochemistry of the system has allowed rational design of inhibitors of this process, which function as antitumor and antiviral agents. © 1995.

引用

页码：793 / 801

页数：9

共 56 条

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