CYCLOPHILIN BINDING TO THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GAG POLYPROTEIN IS MIMICKED BY AN ANTI-CYCLOSPORINE ANTIBODY

被引：9

作者：

FRANKE, EK

CHEN, BX

TATSIS, I

DIAMANDUROS, A

ERLANGER, BF

LUBAN, J

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,NEW YORK,NY 10032

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT MICROBIOL,NEW YORK,NY 10032

[3] COLUMBIA UNIV COLL PHYS & SURG,INST HUMAN NUTR,NEW YORK,NY 10032

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 09期

关键词：

D O I：

10.1128/JVI.69.9.5821-5823.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 is unique among retroviruses in that infectivity requires specific incorporation into virions of the cellular protein cyclophilin A through interactions with the Gag polyprotein. Here we shown that monoclonal antibody B11 1.4, which recognizes a cyclophilin-binding epitope on cyclosporine, detects denatured Or native human immunodeficiency virus type 1 capsid. B11 1.4 does not recognize the capsids of other retroviruses, and binding is inhibited by cyclosporine or by cyclophilin A.

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页码：5821 / 5823

页数：3

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