ANTAGONISM OF 5-HT3 RECEPTORS ATTENUATES THE EFFECTS OF ETHANOL ON EXTRACELLULAR DOPAMINE

被引:129
作者
WOZNIAK, KM [1 ]
PERT, A [1 ]
LINNOILA, M [1 ]
机构
[1] NIMH,BIOL PSYCHIAT BRANCH,BETHESDA,MD 20892
关键词
5-HT[!sub]3[!/sub] receptors; Dopamine; Ethanol; Microdialysis; Nucleus accumbens; Striatum;
D O I
10.1016/0014-2999(90)90015-X
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The effect of a 5-HT3 antagonist, ICS 205-930, on ethanol-induced changes in extracellular dopamine, was investigated with in vivo microdialysis. Pretreatment of rats with ICS 205-930 effectively attenuated the subsequent increases in dopamine, in both the nucleus accumbens and corpus striatum. This suggests that 5-HT may be involved in the effects of ethanol on dopaminergic systems. © 1990.
引用
收藏
页码:287 / 289
页数:3
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