ALL-D-MAGAININ - CHIRALITY, ANTIMICROBIAL ACTIVITY AND PROTEOLYTIC RESISTANCE

被引：306

作者：

BESSALLE, R

KAPITKOVSKY, A

GOREA, A

SHALIT, I

FRIDKIN, M

机构：

[1] WEIZMANN INST SCI,DEPT ORGAN CHEM,IL-76100 REHOVOT,ISRAEL

[2] TEL AVIV SOURASKY MED CTR,INFECT DIS UNIT,CLIN MICROBIOL RES LAB,TEL AVIV,ISRAEL

来源：

FEBS LETTERS | 1990年 / 274卷 / 1-2期

关键词：

All-D-magainin; Proteolytic stability: Clinical potential; Surface-activity;

D O I：

10.1016/0014-5793(90)81351-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

All-D-magainin-2 was synthesized to corroborate experimentally the notion that the biological function of a surface-active peptide stems primarily from its unique amphiphilic α -helical structure. Indeed, the peptide exhibited antibacterial potency nearly identical to that of the all-L-enantiomer. Being highly resistant to proteolysis and non-hemolytic all-D-magainin might have considerable therapeutic importance. © 1990.

引用

页码：151 / 155

页数：5

共 31 条

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