VINYLOGOUS CARBINOLAMINE TUMOR INHIBITORS .4. ANTI-LEUKEMIC ACTIVITY OF DERIVATIVES OF 1,2-DIMETHYL-3,4-BIS(HYDROXYMETHYL)-5-PHENYLPYRROLE BIS(N-METHYLCARBAMATE)

被引：31

作者：

ANDERSON, WK

HALAT, MJ

机构：

[1] Department of Medicinal Chemistry, School of Pharmacy, State University of New York at Buffalo, New York, Amherst

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 08期

关键词：

D O I：

10.1021/jm00194a018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of phenyl-substituted derivatives of 1, 2-dimethyl-3, 4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) (1) were synthesized and tested for antileukemic activity against P388 lymphocytic leukemia in the mouse. All of the compounds tested, 1a-r, showed significant activity in this assay. Selected derivatives of 1 were tested against several bacteria and were found to have little or no antibacterial activity in the systems examined. © 1979, American Chemical Society. All rights reserved.

引用

页码：977 / 980

页数：4

共 11 条

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