COMPARISON OF BACTERIOSTATIC AND BACTERICIDAL ACTIVITY OF ISONIAZID AND ETHIONAMIDE AGAINST MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-TUBERCULOSIS

被引：27

作者：

HEIFETS, LB

LINDHOLMLEVY, PJ

FLORY, M

机构：

[1] UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80262

[2] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DIV PULM SCI,DENVER,CO 80262

来源：

AMERICAN REVIEW OF RESPIRATORY DISEASE | 1991年 / 143卷 / 02期

关键词：

D O I：

10.1164/ajrccm/143.2.268

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Minimal inhibitory and bactericidal concentrations (MIC and MBC) of isoniazid and ethionamide were determined in 7H12 broth in experiments with 68 Mycobacterium avium strains and 14 wild drug-susceptible M. tuberculosis strains. MICs of isoniazid for M. tuberculosis were from 0.025 to 0.05-mu-m/ml, and for M. avium from 0.6 to 10.0-mu-m/ml. MICs of ethionamide for M. tuberculosis were from 0.3 to 1.25-mu-g/ml, and 42.7% of M. avium strains were within the same range. Isonlazid and ethionamide were highly bactericidal against M. tuberculosis, but they had very low bactericidal activity against M. avium.

引用

页码：268 / 270

页数：3

共 28 条

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