CONVULSIVE EFFECTS OF 3-AMINOPYRIDINE ON CORTICAL-NEURONS

被引：32

作者：

BARANYI, A

FEHER, O

机构：

[1] Department of Comparative Physiology, 6701 Szeged

来源：

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY | 1979年 / 47卷 / 06期

关键词：

D O I：

10.1016/0013-4694(79)90303-1

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The authors examined the effects of 3-aminopyridine (3-AP) on pyramidal tract neurones in the motor cortex of anesthetised cats. 3-AP proved to be a strong convulsive agent. Local application of 3-AP in concentrations of 15-20 mM resulted in typical paroxysmal alterations of neuronal activity: (a) enhancement of background firing, (b) augmentation of EPSPs, (c) depression of IPSPs and (d) single and serial paroxysmal depolarization shifts (PDSs). Serial PDSs were reflected by large synchronous waves in the surface ECoG. © 1979.

引用

页码：745 / 751

页数：7

共 45 条

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PHILLIPS C. G., 1959, QUART JOUR EXPTL PHYSIOL, V44, P1

[32] CORTICAL INHIBITORY POSTSYNAPTIC POTENTIALS AND STRYCHNINIZATION [J].