IMPAIRED DEGRADATION OF LEUKOTRIENES IN PATIENTS WITH PEROXISOME DEFICIENCY DISORDERS

被引:63
作者
MAYATEPEK, E
LEHMANN, WD
FAULER, J
TSIKAS, D
FROLICH, JC
SCHUTGENS, RBH
WANDERS, RJA
KEPPLER, D
机构
[1] GERMAN CANC RES CTR, DIV TUMOR BIOCHEM, NEUENHEIMER FELD 280, W-6900 HEIDELBERG, GERMANY
[2] HANNOVER MED SCH, DEPT CLIN PHARMACOL, W-3000 HANNOVER, GERMANY
[3] UNIV HOSP AMSTERDAM, DEPT PEDIAT, 1105 AZ AMSTERDAM, NETHERLANDS
关键词
LEUKOTRIENE ANALYSIS; BETA-OXIDATION; PEROXISOMES; URINARY LEUKOTRIENES; ZELLWEGER SYNDROME;
D O I
10.1172/JCI116309
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The degradation of leukotrienes by beta-oxidation from the omega-end proceeds in peroxisomes (Jedlitschky et al. J. Biol. Chem. 1991. 266:24763-24772). Peroxisomal degradation of leukotrienes was studied in humans by analyses of endogenous leukotrienes in urines from eight patients with biochemically established peroxisome deficiency disorder and eight age- and sex-matched healthy infant controls. Leukotriene metabolites were separated by high-performance liquid chromatography, quantified by radioimmunoassays, and identified as well as quantified by gas chromatography-mass spectrometry. Urinary leukotriene E4 (LTE4) and N-acetyl-LTE4 excretions, relative to creatinine, were increased > 10-fold in the patients in comparison to healthy infants. The beta-oxidation product omega-carboxy-tetranor-LTE3 averaged 0.05 mumol/mol creatinine in the controls but was not detectable in the patients. However, omega-carboxy-LTE4 (median 13.6 mumol/mol creatinine) was significantly increased in the patients' urine, whereas LTB4 (median 0.07 mumol/mol creatinine) and omega-carboxy-LTB4 were detected exclusively in the urines of the patients. These data indicate an impairment of the inactivation and degradation of both LTE4 and LTB4 in patients with peroxisomal deficiency. The increased levels of the biologically active, proinflammatory mediators LTE4 and LTB4 might be of pathophysiological significance in peroxisome deficiency disorders. This is the first and so far only condition with a pronounced urinary excretion of omega-carboxy-LTE4, omega-carboxy-LTB4, and LTB4. This impaired catabolism of leukotrienes and the altered pattern of metabolites may be of diagnostic value. These findings underline the essential role of peroxisomes in the catabolism of leukotrienes in humans.
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页码:881 / 888
页数:8
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